American Journal of Pharmacology and Pharmacotherapeutics Cardiovascular Effect of Pyridazine Derivative Pimobedan and Other Related Compounds

The pyridazine ring is present in various biologically active compounds and some pyridazine compounds have been reported as valuable cardiovascular agents. Benzimidazole-pyridazinone compound, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazole-5-yl]-5-methyl-3(2H)pyridazinone (pimobedan or vetmedin) is a potent cardiovascular agent. It is a non adrenergic, non-glycoside inotropic drug with vasodilator activities and exerts a stimulatory myocardial activity by a dual mechanism of action with raise in calcium sensitivity of cardiac myofilaments and inhibition of phosphodiesterase. Pyridazine is an attractive compound for designing and development of novel pyridazine compounds as cardiotonic agents in future.